Mouse Dkk3 Antibody Pair - BSA and Azide free (RMAB-0252269)
Cat. No.: RMAB-0252269
Category: Antibody Pair
INQUIRY
10 x 96 tests
Mouse Dkk3 Antibody Pair - BSA and Azide free is a matched pair of unconjugated recombinant rabbit monoclonal capture and detection antibodies used to quantify mouse Dkk3 in sandwich ELISAs and many other pair-based applications._x000D_
Product Features
| Conjugate | Unconjugated capture and detector antibodies |
|---|---|
| Species Reactivity | Mouse |
| Range | 39.1 pg/mL - 5000 pg/mL |
| Applications | Sandwich ELISA |
| Key Features | Unconjugated capture and detector antibodies; Adaptable to any antibody pair-based assay format; Antibody concentration ~ 1 mg/mL; BSA and azide free buffer - ready for conjugation; Reacts with: Mouse |
Target Information
| Target Symbol | DKK3 |
|---|---|
| Target Name | Dickkopf-related protein 3 |
| UniProt ID | Q9UBP4 |
| Cellular Localization | Secreted. |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
| Post-translational Modifications | N- and O-glycosylated. |
| Domain | The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6. |
| Sequence Similarities | Belongs to the dickkopf family. |
Storage & Shipping
| Storage & Shipping | Store at 4°C. Please refer to protocols. |
|---|
For research use only. Not for clinical use.
