Anti-Fibronectin Antibody (RMAB-0250589)
Cat. No.: RMAB-0250589
Category: Primary Antibodies
INQUIRY
100 μg
Customer Size
Mouse monoclonal to Fibronectin
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | 10/Fibronectin |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human |
| Immunogen | The details of the immunogen for this antibody are not available. |
| Applications | WB, IHC-P |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Mouse monoclonal to Fibronectin; Suitable for: WB, IHC-P; Knockout validated; Reacts with: Human |
Target Information
| Target Symbol | FN1 |
|---|---|
| Target Name | Fibronectin |
| UniProt ID | P02751 |
| Cellular Localization | Secreted, extracellular space, extracellular matrix. |
| Developmental Stage | Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age. |
| Function | Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. |
| Involvement in Disease | Glomerulopathy with fibronectin deposits 2 |
| Post-translational Modifications | Sulfated. It is not known whether both or only one of Thr-264 and Thr-265 are/is glycosylated. Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e. g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers). Phosphorylated by FAM2C in the extracellular medium. Proteolytic processing produces the C-terminal NC1 peptide, anastellin. |
| Sequence Similarities | Contains 12 fibronectin type-I domains. Contains 2 fibronectin type-II domains. Contains 16 fibronectin type-III domains. |
Storage & Shipping
| Storage Buffer | pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
