Anti-Thrombomodulin Antibody (RMAB-0251154)
Cat. No.: RMAB-0251154
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to Thrombomodulin
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR18217 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Mouse, Rat |
| Immunogen | Recombinant fragment. |
| Applications | WB, IHC-P, Flow Cyt |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Thrombomodulin; Suitable for: WB, IHC-P, Flow Cyt; Reacts with: Mouse, Rat |
Target Information
| Target Symbol | THBD |
|---|---|
| Target Name | Thrombomodulin |
| UniProt ID | P07204 |
| Cellular Localization | Membrane. |
| Function | Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. |
| Involvement in Disease | Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THR-THBD). A hemostatic disorder characterized by a tendency to thrombosis.Defects in THBD are a cause of susceptibility to hemolytic uremic syndrome atypical type 6 (AHUS6). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. |
| Post-translational Modifications | N-glycosylated. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. |
| Sequence Similarities | Contains 1 C-type lectin domain. Contains 6 EGF-like domains. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: 0.05% BSA, 40% Glycerol (glycerin, glycerine), PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
