Anti-TBR2 / Eomes Antibody (RMAB-0251133)
Cat. No.: RMAB-0251133
Category: Primary Antibodies
INQUIRY
50 μg
100 μg
Rabbit polyclonal to TBR2 / Eomes
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Polyclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Purity | Immunogen affinity purified |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide corresponding to Mouse TBR2/ Eomes aa 65 to the C-terminus |
| Applications | IHC-Fr, WB |
| Key Features | Rabbit polyclonal to TBR2 / Eomes; Suitable for: IHC-Fr, WB; Reacts with: Mouse, Human; Isotype: IgG |
Target Information
| Target Symbol | EOMES |
|---|---|
| Target Name | Eomesodermin homolog |
| UniProt ID | O95936 |
| Cellular Localization | Nucleus. |
| Developmental Stage | Detected at 7 weeks of development in the forebrain floorplate of the CNS. Expressed within the mantle layer and migrating neuroblasts of the telencephalon at 12.5 weeks of development. |
| Function | Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. |
| Involvement in Disease | A translocation t(3; 1)(p24; q23) located 215 kb 3' to the EOMES gene but leading to loss of its expression was identified in a large consanguineous family. Homozygous silencing produces microcephaly associated with corpus callosum agenesis, bilateral polymicrogyria, ventricular dilatation and a small cerebellum. |
| Sequence Similarities | Contains 1 T-box DNA-binding domain. |
Storage & Shipping
| Storage Buffer | pH: 7.40; Preservative: 0.02% Sodium azide; Constituent: PBSBatches of this product that have a concentration < 1mg/ml may have BSA added as a stabilising agent. If you would like information about the formulation of a specific lot, please contact our scientific support team who will be happy to help. |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
