Anti-Flightless I Antibody (RMAB-0250596)
Cat. No.: RMAB-0250596
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to Flightless I
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR4201 |
| Form | Liquid |
| Purity | Tissue culture supernatant |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide. |
| Applications | WB, IHC-P, ICC/IF |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Flightless I; Suitable for: WB, IHC-P, ICC/IF; Reacts with: Human |
Target Information
| Target Symbol | FLII |
|---|---|
| Target Name | Protein flightless-1 homolog |
| UniProt ID | Q13045 |
| Cellular Localization | Nucleus. Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Colocalizes to actin-rich structures in blastocysts and, together with HRAS1, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes. |
| Function | May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration. |
| Involvement in Disease | Deletion of the FLII gene may be a cause of Smith-Magenis syndrome (SMS). It is a contiguous gene deletion syndrome involving developmental abnormalities and mental retardation. The spectrum of clinical findings includes short stature, brachydactyly, developmental delay, dysmorphic features, sleep disturbances, and behavioral problems. |
| Sequence Similarities | Contains 5 gelsolin-like repeats. Contains 15 LRR (leucine-rich) repeats. |
Storage & Shipping
| Storage Buffer | pH: 7.20; Preservative: 0.05% Sodium azide; Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. |
For research use only. Not for clinical use.
