Anti-GATA1 Rabbit Monoclonal Antibody (RMAB-0251510)
Cat. No.: RMAB-0251510
Category: Primary Antibodies
Research Area: Stem Cells, Epigenetics
INQUIRY
100 μL
Customer Size
Anti-GATA1 Rabbit Monoclonal Antibody. Tested in ChIP, IP, IF, WB applications. This antibody reacts with Human.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human |
| Immunogen | Recombinant fragment. |
| Applications | WB, Flow Cyt, IHC, IP |
Target Information
| Target Symbol | GATA1 |
|---|---|
| Target Name | Erythroid transcription factor |
| UniProt ID | P15976 |
| Function | Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequenceGATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. |
| Involvement in Disease | Defects in GATA1 are the cause of X-linked dyserythropoietic anemia and thrombocytopenia (XDAT). XDAT is a disorder characterized by erythrocytes with abnormal size and shape, and paucity of platelets in peripheral blood. The bone marrow contains abundant and abnormally small megakaryocytes.Defects in GATA1 are the cause of X-linked thrombocytopenia with beta-thalassemia (XLTT); also knwon as thrombocytopenia, platelet dysfunction, hemolysis, and imbalanced globin synthesis. XLTT consists of an unusual form of thrombocytopenia with beta-thalassemia. Patients have splenomegaly and petechiae, moderate thrombocytopenia, prolonged bleeding time due to platelet dysfunction, reticulocytosis and unbalanced hemoglobin chain synthesis resembling that of beta-thalassemia minor.Defects in GATA1 are the cause of anemia without thrombocytopenia X-linked (XLAWT). XLAWT is a form of anemia characterized by abnormal morphology of erythrocytes and granulocytes in peripheral blood, bone marrow dysplasia with hypocellularity of erythroid and granulocytic lineages, and normal or increased number of megakaryocytes. Neutropenia of a variable degree is present in affected individuals. |
| Post-translational Modifications | Highly phosphorylated on serine residues. Phosphorylation on Ser-31 is enhanced on erythroid differentiation. Phosphorylation on Ser-142 promotes sumoylation on Lys-137. Sumoylation on Lys-137 is enhanced by phosphorylation on Ser-142 and by interaction with PIAS4. Sumoylation by SUMO1 has no effect on transcriptional activity. |
| Domain | The two fingers are functionally distinct and cooperate to achieve specific, stable DNA binding. The first finger is necessary only for full specificity and stability of binding, whereas the second one is required for binding. |
| Sequence Similarities | Contains 2 GATA-type zinc fingers. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
