Anti-GSK3 beta Antibody (RMAB-0250666)
Cat. No.: RMAB-0250666
Category: Primary Antibodies
INQUIRY
10 μL
100 μL
Rabbit monoclonal to GSK3 beta
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | Y174 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Recombinant fragment |
| Immunogen | Synthetic peptide. |
| Applications | ICC/IF, Flow Cyt (Intra), WB, IHC-P, ELISA |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to GSK3 beta; Suitable for: ICC/IF, Flow Cyt (Intra), WB, IHC-P, ELISA; Knockout validated; Reacts with: Human, Recombinant fragment |
Target Information
| Target Symbol | GSK3B |
|---|---|
| Target Name | Glycogen synthase kinase-3 beta |
| UniProt ID | P49841 |
| Cellular Localization | Cytoplasm. Nucleus. Cell membrane. The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane. |
| Function | Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. |
| Post-translational Modifications | Phosphorylated by AKT1 and ILK1. Activated by phosphorylation at Tyr-216. |
| Sequence Similarities | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. Contains 1 protein kinase domain. |
Storage & Shipping
| Storage Buffer | pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol, 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
For research use only. Not for clinical use.
