Anti-HDAC6 Antibody (RMAB-0250699)
Cat. No.: RMAB-0250699
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to HDAC6
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR1698(2) |
| Form | Liquid |
| Purity | Tissue culture supernatant |
| Species Reactivity | Human, African green monkey |
| Immunogen | Synthetic peptide within Human HDAC6 aa 1-1 (N terminal). The exact sequence is proprietary. |
| Applications | Flow Cyt (Intra), WB, IHC-P |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to HDAC6; Suitable for: Flow Cyt (Intra), WB, IHC-P; Knockout validated; Reacts with: Human, African green monkey |
Target Information
| Target Symbol | HDAC6 |
|---|---|
| Target Name | Histone deacetylase 6 |
| UniProt ID | Q9UBN7 |
| Cellular Localization | Nucleus. Cytoplasm. It is mainly cytoplasmic, where it is associated with microtubules. |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. |
| Post-translational Modifications | Ubiquitinated. Its polyubiquitination however does not lead to its degradation. Sumoylated in vitro. |
| Sequence Similarities | Belongs to the histone deacetylase family. HD type 2 subfamily. Contains 1 UBP-type zinc finger. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.05% Sodium azide; Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
