Anti-HDAC8/Histone Deacetylase 8 Rabbit Monoclonal Antibody (RMAB-0251397)
Cat. No.: RMAB-0251397
Category: Primary Antibodies
Research Area: Cardiovascular, Stem Cells, Epigenetics
INQUIRY
100 μL
Customer Size
Anti-HDAC8/Histone Deacetylase 8 Rabbit Monoclonal Antibody. Tested in IP, WB applications. This antibody reacts with Human, Mouse, Rat.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide. |
| Applications | WB, IHC, IF, ICC |
Target Information
| Target Symbol | HDAC8 |
|---|---|
| Target Name | Histone deacetylase 8 |
| UniProt ID | Q9BY41 |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility. |
| Post-translational Modifications | Phosphorylated by PKA on serine 39. Phosphorylation reduces deacetylase activity observed preferentially on histones H3 and H4. |
| Sequence Similarities | Belongs to the histone deacetylase family. HD type 1 subfamily. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
