Anti-Human CD25 Antibody (RMAB-0251949)
Cat. No.: RMAB-0251949
Category: Primary Antibodies
Research Area: Cell Therapy Research, Immunology
INQUIRY
50 Tests
Customer Size
The 2A3 antibody reacts with human CD25, a 55 kDa type I integral transmembrane glycoprotein also known as low-affinity interleukin 2 receptor alpha chain (IL-2Rα) or Tac antigen. CD25 is present on activated T and B cells, monocytes, macrophages, and regulatory T cells. CD25 has a role in T lymphocyte activation and can be used in the identification of T cell subsets in viral infections like HIV and HTLV. CD25 associates with IL-2 receptor β (CD122) and common γ (CD132) chains to form a high-affinity IL-2R complex. The 2A3 antibody binds to an epitope on p55 at or near the IL-2 binding site and prevents high-affinity IL-2 binding to T lymphocytes. Daclizumab, a therapeutic humanized monoclonal antibody, blocks the binding of 2A3 antibody.
Product Features
| Host Species | Mouse |
|---|---|
| Conjugate | PE |
| Species Reactivity | Cynomolgus, Human |
| Applications | Cell Isolation, Flow Cyt |
| Key Features | PE |
Target Information
| Target Symbol | CD25 |
|---|---|
| Target Name | CD25 |
For research use only. Not for clinical use.
