Anti-Human HB-EGF Polyclonal Antibody (RMAB-0251611)
Cat. No.: RMAB-0251611
Category: Primary Antibodies
INQUIRY
50 μg
100 μg
Product Features
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Immunogen | E.coli-derived, 9.7 kDa Recombinant Human HB-EGF |
Target Information
| Target Symbol | HBEGF |
|---|---|
| Target Name | Proheparin-binding EGF-like growth factor |
| UniProt ID | Q99075 |
| Cellular Localization | [Heparin-binding EGF-like growth factor]: Secreted, extracellular space. Mature HB-EGF is released into the extracellular space and probably binds to a receptor.: Cell membrane; Single-pass type I membrane protein. |
| Function | Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. |
| Post-translational Modifications | Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active. O-glycosylated with core 1 or possibly core 8 glycans. Thr-47 is a minor glycosylation site compared to Thr-44. |
For research use only. Not for clinical use.
