Anti-Integrin alpha 4/CD49D Antibody (RMAB-0250753)
Cat. No.: RMAB-0250753
Category: Primary Antibodies
INQUIRY
100 μg
Customer Size
Mouse monoclonal to Integrin alpha 4/CD49D
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | HP2/1 |
| Form | Liquid |
| Purity | Protein G purified |
| Species Reactivity | Human |
| Immunogen | Tissue, cells or virus corresponding to Human Integrin alpha 4/CD49D. JM leukaemia line. |
| Applications | ICC/IF |
| Key Features | Mouse monoclonal to Integrin alpha 4/CD49D; Suitable for: ICC/IF; Knockout validated; Reacts with: Human; Isotype: IgG1 |
Target Information
| Target Symbol | ITGA4 |
|---|---|
| Target Name | Integrin alpha-4 |
| UniProt ID | P13612 |
| Cellular Localization | Membrane. |
| Function | Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. |
| Post-translational Modifications | Phosphorylation on Ser-127 inhibits PXN binding. |
| Myeloma | x63-Ag8.653 |
| Domain | The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion. |
| Sequence Similarities | Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. |
Storage & Shipping
| Storage Buffer | pH: 7.40; Preservative: 0.09% Sodium azide; Constituent: PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
