Anti-NEFM/Nf M Rabbit Monoclonal Antibody (RMAB-0251527)
Cat. No.: RMAB-0251527
Category: Primary Antibodies
Research Area: Stem Cells, Neuroscience
INQUIRY
100 μL
Customer Size
Anti-NEFM/Nf M Rabbit Monoclonal Antibody. Tested in IP, IF, WB applications. This antibody reacts with Human.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide. |
| Applications | WB, Flow Cyt, IHC, IF, ICC |
Target Information
| Target Symbol | NEFM |
|---|---|
| Target Name | Neurofilament medium polypeptide |
| UniProt ID | P07197 |
| Function | Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. |
| Post-translational Modifications | There are a number of repeats of the tripeptide K-S-P, NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincidentally with a change in the neurofilament function. Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization. |
| Sequence Similarities | Belongs to the intermediate filament family. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
