Anti-Nestin Antibody (RMAB-0250895)
Cat. No.: RMAB-0250895
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Mouse monoclonal to Nestin
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | 2C1.3A11 |
| Form | Liquid |
| Purity | Protein G purified |
| Species Reactivity | Human |
| Immunogen | A 15 amino acid fragment from the cloned human Nestin. |
| Applications | ICC/IF, WB, Flow Cyt, IHC-P |
| Key Features | Mouse monoclonal to Nestin; Suitable for: ICC/IF, WB, Flow Cyt, IHC-P; Knockout validated; Reacts with: Human; Isotype: IgG1 |
Target Information
| Target Symbol | NES |
|---|---|
| Target Name | Nestin |
| UniProt ID | P48681 |
| Developmental Stage | Upon terminal neural differentiation, nestin is down-regulated and replaced by neurofilaments. |
| Function | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells. |
| Post-translational Modifications | Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized. |
| Sequence Similarities | Belongs to the intermediate filament family. |
Storage & Shipping
| Storage Buffer | Preservative: 0.1% Sodium azide; Constituent: PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
