Anti-Nicastrin Antibody (RMAB-0250906)
Cat. No.: RMAB-0250906
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to Nicastrin
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR2575Y |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide within Human Nicastrin aa 65-75 (C terminal). The exact sequence is proprietary. |
| Applications | WB |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Nicastrin; Suitable for: WB; Knockout validated; Reacts with: Mouse, Rat, Human |
Target Information
| Target Symbol | NCSTN |
|---|---|
| Target Name | Nicastrin |
| UniProt ID | Q92542 |
| Cellular Localization | Membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Function | Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. |
| Sequence Similarities | Belongs to the nicastrin family. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.05% Sodium azide; Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant |
|---|---|
| Storage & Shipping | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
For research use only. Not for clinical use.
