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Anti-Nicastrin Antibody (RMAB-0250906)

Cat. No.: RMAB-0250906

Category: Primary Antibodies

INQUIRY 100 μL Customer Size
Rabbit monoclonal to Nicastrin

Product Features

Isotype IgG
Clonality Monoclonal
Host Species Rabbit
Clone Number EPR2575Y
Form Liquid
Purity Protein A purified
Species Reactivity Human, Mouse, Rat
Immunogen Synthetic peptide within Human Nicastrin aa 65-75 (C terminal). The exact sequence is proprietary.
Applications WB
Key Features Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Nicastrin; Suitable for: WB; Knockout validated; Reacts with: Mouse, Rat, Human

Target Information

Target Symbol NCSTN
Target Name Nicastrin
UniProt ID Q92542
Cellular Localization Membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Function Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
Sequence Similarities Belongs to the nicastrin family.

Storage & Shipping

Storage Buffer pH: 7.2; Preservative: 0.05% Sodium azide; Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant
Storage & Shipping Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

For research use only. Not for clinical use.