Anti-Nodal Antibody (RMAB-0250914)
Cat. No.: RMAB-0250914
Category: Primary Antibodies
INQUIRY
100 μg
Customer Size
Mouse monoclonal to Nodal
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | 5C3 |
| Form | Liquid |
| Purity | Tissue culture supernatant |
| Species Reactivity | Human, Mouse |
| Immunogen | Recombinant fragment: RCEGECPNPV GEEFHPTNHA YIQSLLKRYQ PHRVPSTCCA PVKTKPLSML YVDNGRVLLD HHKDMIVEEC GC, corresponding to amino acids 275-347 of Human Nodal |
| Applications | WB, IHC-P, ICC/IF, Flow Cyt |
| Key Features | Mouse monoclonal to Nodal; Suitable for: WB, IHC-P, ICC/IF, Flow Cyt; Reacts with: Mouse, Human; Isotype: IgG1 |
Target Information
| Target Symbol | NODAL |
|---|---|
| Target Name | Nodal homolog |
| UniProt ID | Q96S42 |
| Cellular Localization | Secreted. |
| Function | Essential for mesoderm formation and axial patterning during embryonic development. |
| Involvement in Disease | Defects in NODAL are the cause of visceral heterotaxy autosomal type 5 (HTX5). A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects. Clinical features of visceral heterotaxy autosomal type 5 include situs inversus viscerum or situs ambiguus, congenital heart defect, transposition of the great vessels ventricular septal defect, atrial septal defect, truncuscommunis, and dextrocardia. |
| Sequence Similarities | Belongs to the TGF-beta family. |
Storage & Shipping
| Storage Buffer | pH: 7.4 |
|---|---|
| Storage & Shipping | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
For research use only. Not for clinical use.
