Anti-PCSK9 Antibody (RMAB-0250959)
Cat. No.: RMAB-0250959
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to PCSK9
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR17827-117 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Mouse |
| Immunogen | Recombinant fragment. |
| Applications | Flow Cyt (Intra), WB, ICC/IF, IP |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to PCSK9; Suitable for: Flow Cyt (Intra), WB, ICC/IF, IP; Reacts with: Mouse |
Target Information
| Target Symbol | PCSK9 |
|---|---|
| Target Name | Proprotein convertase subtilisin/kexin type 9 |
| UniProt ID | Q8NBP7 |
| Cellular Localization | Secreted. |
| Function | May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis. |
| Involvement in Disease | Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3). FH3 inheritance is autosomal dominant. |
| Post-translational Modifications | The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme. |
| Sequence Similarities | Belongs to the peptidase S8 family. Contains 1 peptidase S8 domain. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
