Anti-Phospho-c-Myc (T58 + S62) Rabbit Monoclonal Antibody (RMAB-0251518)
Cat. No.: RMAB-0251518
Category: Primary Antibodies
Research Area: Cancer Research, Stem Cells
INQUIRY
100 μL
Customer Size
Anti-Phospho-c-Myc (T58 + S62) Rabbit Monoclonal Antibody. Tested in IP, IF, WB applications. This antibody reacts with Human, Rat.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human, Rat |
| Applications | WB, IHC |
Target Information
| Target Symbol | MYC |
|---|---|
| Target Name | Myc proto-oncogene protein |
| UniProt ID | P01106 |
| Function | Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes. |
| Involvement in Disease | Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors.A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8; 12)(q24; q22) with BTG1.Defects in MYC are a cause of Burkitt lymphoma (BL). A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8; 14), t(8; 22) or t(2; 8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
