Anti-Phospho-PP2A alpha (Y307) PPP2CA Rabbit Monoclonal Antibody (RMAB-0251460)
Cat. No.: RMAB-0251460
Category: Primary Antibodies
Research Area: Cardiovascular, Cancer Research, Stem Cells, Neuroscience
INQUIRY
100 μL
Customer Size
Anti-Phospho-PP2A alpha (Y307) PPP2CA Rabbit Monoclonal Antibody. Tested in IP, IF, WB applications. This antibody reacts with Human, Mouse, Rat.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human, Mouse, Rat |
| Applications | WB, Flow Cyt, IF, ICC |
Target Information
| Target Symbol | PPP2CA |
|---|---|
| Target Name | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform |
| UniProt ID | P67775 |
| Function | PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV4 large T antigen and p53/TP53. Dephosphorylates SV4 large T antigen, preferentially on serine residues 12, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen. Activates RAF1 by dephosphorylating it at 'Ser-259'. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
