Anti-SCF Rabbit Monoclonal Antibody (RMAB-0251381)
Cat. No.: RMAB-0251381
Category: Primary Antibodies
Research Area: Immunology, Stem Cells
INQUIRY
100 μL
Customer Size
Anti-SCF Rabbit Monoclonal Antibody. Tested in IF, WB applications. This antibody reacts with Human.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide within Human SCF aa 5-15 (N terminal). The exact sequence is proprietary. |
| Applications | WB, IHC, IF, ICC, IP |
Target Information
| Target Symbol | KITLG |
|---|---|
| Target Name | Kit ligand |
| UniProt ID | P21583 |
| Developmental Stage | Acts in the early stages of hematopoiesis. |
| Function | Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. |
| Involvement in Disease | Hyperpigmentation with or without hypopigmentation, familial progressiveDeafness, congenital, unilateral or asymmetric |
| Post-translational Modifications | A soluble form (sKITLG) is produced by proteolytic processing of isoform 1 in the extracellular domain. Found in two differentially glycosylated forms, LMW-SCF and HMW-SCF. LMW-SCF is fully N-glycosylated at Asn-145, partially N-glycosylated at Asn-9, O-glycosylated at Ser-167, Thr-168 and Thr-18, and not glycosylated at Asn-97 or Asn-118. HMW-SCF is N-glycosylated at Asn-118, Asn-9 and Asn-145, O-glycosylated at Ser-167, Thr-168 and Thr-18, and not glycosylated at Asn-97. A soluble form exists as a cleavage product of the extracellular domain. |
| Sequence Similarities | Belongs to the SCF family. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
