Anti-SFRP1 Rabbit Monoclonal Antibody (RMAB-0251402)
Cat. No.: RMAB-0251402
Category: Primary Antibodies
Research Area: Stem Cells, Neuroscience
INQUIRY
100 μL
Customer Size
Anti-SFRP1 Rabbit Monoclonal Antibody. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human |
| Immunogen | Recombinant fragment. |
| Applications | WB, IHC |
Target Information
| Target Symbol | SFRP1 |
|---|---|
| Target Name | Secreted frizzled-related protein 1 |
| UniProt ID | Q8N474 |
| Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. |
| Domain | The FZ domain is involved in binding with Wnt ligands. |
| Sequence Similarities | Belongs to the secreted frizzled-related protein (sFRP) family. Contains 1 FZ (frizzled) domain. Contains 1 NTR domain. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
