Anti-Slow Skeletal Myosin Heavy chain Antibody (RMAB-0251034)
Cat. No.: RMAB-0251034
Category: Primary Antibodies
INQUIRY
50 μL
Customer Size
Mouse monoclonal to Slow Skeletal Myosin Heavy chain
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | NOQ7.5.4D |
| Form | Liquid |
| Purity | Proprietary Purification |
| Species Reactivity | Rat, Rabbit |
| Immunogen | Full length native protein (purified) corresponding to Human Slow Skeletal Myosin Heavy chain. Human skeletal muscle myosin purified from myofibrils. |
| Applications | IHC-P, WB |
| Key Features | Mouse monoclonal to Slow Skeletal Myosin Heavy chain; Suitable for: IHC-P, WB; Reacts with: Rat, Rabbit; Isotype: IgG1 |
Target Information
| Target Symbol | MYH7 |
|---|---|
| Target Name | Myosin-7 |
| UniProt ID | P12883 |
| Cellular Localization | Cytoplasm > myofibril. Thick filaments of the myofibrils. |
| Function | Muscle contraction. |
| Involvement in Disease | Defects in MYH7 are the cause of cardiomyopathy familial hypertrophic type 1 (CMH1). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.Defects in MYH7 are the cause of myopathy myosin storage (MYOMS). In this disorder, muscle biopsy shows type 1 fiber predominance and increased interstitial fat and connective tissue. Inclusion bodies consisting of the beta cardiac myosin heavy chain are present in the majority of type 1 fibers, but not in type 2 fibers.Defects in MYH7 are the cause of scapuloperoneal myopathy MYH7-related (SPMM); also known as scapuloperoneal syndrome myopathic type. SPMM is a progressive muscular atrophia beginning in the lower legs and affecting the shoulder region earlier and more severely than distal arm.Defects in MYH7 are a cause of cardiomyopathy dilated type 1S (CMD1S). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.Defects in MYH7 are the cause of myopathy distal type 1 (MPD1). MPD1 is a muscular disorder characterized by early-onset selective weakness of the great toe and ankle dorsiflexors, followed by weakness of the finger extensors. Mild proximal weakness occasionally develops years later after the onset of the disease. |
| Domain | The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2). |
| Sequence Similarities | Contains 1 IQ domain. Contains 1 myosin head-like domain. |
Storage & Shipping
| Storage Buffer | pH: 7.40; Preservative: 0.097% Sodium azide; Constituent: PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
For research use only. Not for clinical use.
