Anti-SMAD5 Antibody (RMAB-0251066)
Cat. No.: RMAB-0251066
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to SMAD5
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EP619Y |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Mouse, Rat, Human, African green monkey |
| Immunogen | Synthetic peptide within Human SMAD5 aa 2-3. The exact sequence is proprietary. |
| Applications | Flow Cyt (Intra), IHC-P, WB, ICC/IF, Dot blot |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to SMAD5; Suitable for: Flow Cyt (Intra), IHC-P, WB, ICC/IF, Dot blot; Reacts with: Mouse, Rat, Human, African green monkey |
Target Information
| Target Symbol | SMAD5 |
|---|---|
| Target Name | Mothers against decapentaplegic homolog 5 |
| UniProt ID | Q99717 |
| Cellular Localization | Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. |
| Function | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). |
| Post-translational Modifications | Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase. Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1. |
| Sequence Similarities | Belongs to the dwarfin/SMAD family. Contains 1 MH1 (MAD homology 1) domain. Contains 1 MH2 (MAD homology 2) domain. |
Storage & Shipping
| Storage Buffer | pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 40% Glycerol, 0.05% BSA, 59% PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
