Anti-SOX2 Rabbit Monoclonal Antibody (RMAB-0251468)
Cat. No.: RMAB-0251468
Category: Primary Antibodies
Research Area: Stem Cells, Epigenetics, Neuroscience
INQUIRY
100 μL
Customer Size
Anti-SOX2 Rabbit Monoclonal Antibody. Tested in IF, IHC, WB applications. This antibody reacts with Human, Mouse.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide. |
| Applications | WB, IHC, IF, ICC |
Target Information
| Target Symbol | SOX2 |
|---|---|
| Target Name | Transcription factor SOX-2 |
| UniProt ID | P48431 |
| Function | Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP26 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. |
| Involvement in Disease | Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula. |
| Post-translational Modifications | Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation. |
| Sequence Similarities | Contains 1 HMG box DNA-binding domain. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
