Anti-STAT3 Rabbit Monoclonal Antibody (RMAB-0251121)
Cat. No.: RMAB-0251121
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human |
| Applications | WB, IHC, IF, ICC, IP |
| Key Features | Bio Anti-STAT3 Rabbit Monoclonal Antibody. Tested in IP, IF, WB applications. This antibody reacts with Human. |
Target Information
| Target Symbol | STAT3 |
|---|---|
| Target Name | Signal transducer and activator of transcription 3 |
| UniProt ID | P40763 |
| Function | Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:1824258). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. |
| Involvement in Disease | Hyperimmunoglobulin E recurrent infection syndrome, autosomal dominantAutoimmune disease, multisystem, infantile-onset |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
