Anti-T-bet / Tbx21 Antibody (RMAB-0251131)
Cat. No.: RMAB-0251131
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to T-bet / Tbx21
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | BLR110H |
| Form | Liquid |
| Purity | Immunogen affinity purified |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide within Human T-bet/ Tbx21 aa 485-535 (C terminal). The exact sequence is proprietary. |
| Applications | WB, IP, ICC, IHC-P |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to T-bet / Tbx21; Suitable for: WB, IP, ICC, IHC-P; Reacts with: Human |
Target Information
| Target Symbol | TBX21 |
|---|---|
| Target Name | T-box transcription factor TBX21 |
| UniProt ID | Q9UL17 |
| Cellular Localization | Nucleus. |
| Function | Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs. |
| Involvement in Disease | Genetic variations in TBX21 are associated with susceptibility to asthma with nasal polyps and aspirin intolerance (ANPAI). A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities. |
| Sequence Similarities | Contains 1 T-box DNA-binding domain. |
Storage & Shipping
| Storage Buffer | pH: 8.20; Preservative: 0.09% Sodium azide; Constituent: 99% Borate buffered saline |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
