Anti-TBR2 / Eomes Antibody (RMAB-0251136)
Cat. No.: RMAB-0251136
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to TBR2 / Eomes
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR21950-241 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide. |
| Applications | IHC-P, IHC-Fr, ICC/IF, IP |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to TBR2 / Eomes; Suitable for: IHC-P, IHC-Fr, ICC/IF, IP; Reacts with: Mouse, Rat, Human |
Target Information
| Target Symbol | EOMES |
|---|---|
| Target Name | Eomesodermin homolog |
| UniProt ID | O95936 |
| Cellular Localization | Nucleus. |
| Developmental Stage | Detected at 7 weeks of development in the forebrain floorplate of the CNS. Expressed within the mantle layer and migrating neuroblasts of the telencephalon at 12.5 weeks of development. |
| Function | Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. |
| Involvement in Disease | A translocation t(3; 1)(p24; q23) located 215 kb 3' to the EOMES gene but leading to loss of its expression was identified in a large consanguineous family. Homozygous silencing produces microcephaly associated with corpus callosum agenesis, bilateral polymicrogyria, ventricular dilatation and a small cerebellum. |
| Sequence Similarities | Contains 1 T-box DNA-binding domain. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol, 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
