Anti-TCF-4 Antibody (RMAB-0251140)
Cat. No.: RMAB-0251140
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to TCF-4
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | NCI-R159-6 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Mouse |
| Immunogen | Recombinant fragment. |
| Applications | Flow Cyt (Intra), WB, ChIP, IHC |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to TCF-4; Suitable for: Flow Cyt (Intra), WB, ChIP, IHC; Reacts with: Mouse, Human |
Target Information
| Target Symbol | TCF4 |
|---|---|
| Target Name | Transcription factor 4 |
| UniProt ID | P15884 |
| Cellular Localization | Nucleus. |
| Function | Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. |
| Involvement in Disease | Defects in TCF4 are a cause of Pitt-Hopkins syndrome (PTHS). PTHS is a rare syndromic encephalopathy characterized by severe psychomotor delay, epilepsy, daily bouts of diurnal hyperventilation starting in infancy, mild postnatal growth retardation, postnatal microcephaly, and distinctive facial features. Since most hitherto reported cases have been sporadic, with males and females equally affected, PTHS is regarded as an autosomal dominant condition. |
| Domain | the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. |
| Sequence Similarities | Contains 1 basic helix-loop-helix (bHLH) domain. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
