Anti-TCF3 / E2A Antibody (RMAB-0251138)
Cat. No.: RMAB-0251138
Category: Primary Antibodies
INQUIRY
100 μg
Customer Size
Rat monoclonal to TCF3 / E2A
Product Features
| Isotype | IgG2b |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rat |
| Clone Number | 7H3 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Mouse, Rat |
| Immunogen | Recombinant fragment. |
| Applications | IHC-P, WB |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rat monoclonal to TCF3 / E2A; Suitable for: IHC-P, WB; Reacts with: Mouse, Rat |
Target Information
| Target Symbol | TCF3 |
|---|---|
| Target Name | Transcription factor E2-alpha |
| UniProt ID | P15923 |
| Cellular Localization | Nucleus. |
| Function | Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. |
| Involvement in Disease | Chromosomal aberrations involving TCF3 are cause of forms of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1; 19)(q23; p13.3) with PBX1; Translocation t(17; 19)(q22; p13.3) with HLF. Inversion inv(19)(p13; q13) with TFPT. |
| Post-translational Modifications | Phosphorylated following NGF stimulation. |
| Domain | the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. |
| Sequence Similarities | Contains 1 basic helix-loop-helix (bHLH) domain. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
