Anti-Themis Antibody (RMAB-0251153)
Cat. No.: RMAB-0251153
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to Themis
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR7353 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide within Human Themis aa 2-3. The exact sequence is proprietary. |
| Applications | IP, Flow Cyt (Intra), WB, ICC/IF |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Themis; Suitable for: IP, Flow Cyt (Intra), WB, ICC/IF; Reacts with: Mouse, Rat, Human |
Target Information
| Target Symbol | THEMIS |
|---|---|
| Target Name | Protein THEMIS |
| UniProt ID | Q8N1K5 |
| Cellular Localization | Cytoplasm. Nucleus. |
| Function | Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. |
| Post-translational Modifications | Phosphorylated on Tyr residues quickly after TCR stimulation. |
| Sequence Similarities | Belongs to the themis family. |
Storage & Shipping
| Storage Buffer | pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
