Anti-Troponin T TNNT2 Rabbit Monoclonal Antibody (RMAB-0251375)
Cat. No.: RMAB-0251375
Category: Primary Antibodies
Research Area: Cardiovascular, Stem Cells
INQUIRY
100 μL
Customer Size
Anti-Troponin T TNNT2 Rabbit Monoclonal Antibody. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Other Immunogen Type corresponding to Human Cardiac Troponin T aa 171-19. |
| Applications | WB, IHC, IF, ICC |
Target Information
| Target Symbol | TNNT2 |
|---|---|
| Target Name | Troponin T, cardiac muscle |
| UniProt ID | P45379 |
| Function | Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| Involvement in Disease | Defects in TNNT2 are the cause of cardiomyopathy familial hypertrophic type 2 (CMH2). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.Defects in TNNT2 are the cause of cardiomyopathy dilated type 1D (CMD1D). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.Defects in TNNT2 are the cause of cardiomyopathy familial restrictive type 3 (RCM3). Restrictive cardiomyopathy is a heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function. |
| Myeloma | Sp2/ |
| Sequence Similarities | Belongs to the troponin T family. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
