Anti-Twist Antibody (RMAB-0251177)
Cat. No.: RMAB-0251177
Category: Primary Antibodies
INQUIRY
100 μg
Customer Size
Mouse monoclonal to Twist
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | Twist2C1a |
| Form | Liquid |
| Purity | Protein G purified |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Recombinant fragment corresponding to Human Twist (C terminal). |
| Applications | WB, ICC |
| Key Features | Mouse monoclonal to Twist; Suitable for: WB, ICC; Reacts with: Mouse, Rat, Human; Isotype: IgG1 |
Target Information
| Target Symbol | TWIST1 |
|---|---|
| Target Name | Twist-related protein 1 |
| UniProt ID | Q15672 |
| Cellular Localization | Nucleus. |
| Function | Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. |
| Involvement in Disease | Defects in TWIST1 are a cause of Saethre-Chotzen syndrome (SCS); also known as acrocephalosyndactyly type 3 (ACS3). SCS is a craniosynostosis syndrome characterized by coronal synostosis, brachycephaly, low frontal hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.Defects in TWIST1 are the cause of Robinow-Sorauf syndrome (RSS); also known as craniosynostosis-bifid hallux syndrome. RSS is an autosomal dominant defect characterized by minor skull and limb anomalies which is very similar to Saethre-Chotzen syndrome.Defects in TWIST1 are the cause of craniosynostosis type 1 (CRS1). Craniosynostosis consists of premature fusion of one or more cranial sutures, resulting in an abnormal head shape. |
| Sequence Similarities | Contains 1 basic helix-loop-helix (bHLH) domain. |
Storage & Shipping
| Storage Buffer | pH: 7.40; Preservative: 0.05% Sodium azide; Constituents: 1% BSA, PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
