Anti-YB1 YBX1 Rabbit Monoclonal Antibody (RMAB-0251371)
Cat. No.: RMAB-0251371
Category: Primary Antibodies
Research Area: Cancer Research, Stem Cells, Epigenetics
INQUIRY
100 μL
Customer Size
Anti-YB1 YBX1 Rabbit Monoclonal Antibody. Tested in Flow Cytometry, IP, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide within Human YB1 aa 25 to the C-terminus |
| Applications | WB, IHC |
Target Information
| Target Symbol | YBX1 |
|---|---|
| Target Name | Y-box-binding protein 1 |
| UniProt ID | P67809 |
| Function | Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability.The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation. |
| Post-translational Modifications | Ubiquitinated by RBBP6; leading to a decrease of YBX1 transcativational ability. In the absence of phosphorylation the protein is retained in the cytoplasm. Cleaved by a 2S proteasomal protease in response to agents that damage DNA. Cleavage takes place in the absence of ubiquitination and ATP. The resulting N-terminal fragment accumulates in the nucleus. |
| Sequence Similarities | Contains 1 CSD (cold-shock) domain. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
