AR-A014418, GSK-3 inhibitor (RMML-00120401)
Cat. No.: RMML-00120401
Category: Inhibitors & Activators
INQUIRY
50 mg
10 mg
Highly selective GSK-3 inhibitor
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 99% |
| Key Features | Highly selective GSK-3 inhibitor; CAS Number: 487021-52-3; Purity: > 99%; Soluble in DMSO to 100 mM; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | GSK-3 |
|---|---|
| Biological Description | Highly selective GSK-3 inhibitor (IC50 = 104 nM). ATP competitive (Ki = 38 nM). Selective over cdc2, cdc5 and 26 other kinases. Inhibits tau phosphorylation (ser 396) at a GSK-3 specific site. Blood-brain barrier permeable. |
| CAS Number | 487021-52-3 |
| Chemical Name | N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea |
| SMILES | O=C(Nc1ncc(s1)[N+]([O-])=O)NCc2ccc(OC)cc2 |
| Molecular Formula | C12H12N4O4S |
| Molecular Weight | 308.31 Da |
| PubChem Identifier | 448014 |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information. |
|---|---|
| Solubility | Soluble in DMSO to 100 mM |
| Storage & Shipping | Store at 4°C. The product can be stored for up to 12 months. |
For research use only. Not for clinical use.
