SMER28

SMER28, a bromo-substituted quinazoline, was first identified as a small-molecule enhancer of rapamycin. SMER28 induces autophagy by increasing autophagosome synthesis and enhancing the clearance of model autophagy substrates. As a component of a neural reprogramming cocktail, SMER28 reprograms mouse fibroblasts into induced neural stem cell-like cells. Enhances clearance of autophagy substrates including mutant huntingtin in Huntington's disease and A53T α-synuclein in familial Parkinson's disease. Throμgh autophagy factor ATG5, stimulates erythropoiesis and up-regulates expression of globin genes in both in vitro and in vivo models of Diamond-Blackfan anemia. Decreases the level of indicators of Alzheimer's disease.