β-Nicotinamide Mononucleotide

Maintain cell quality and reduce cell aging with β-nicotinamide mononucleotide. β-NMN has been used for:LDelays apoptosis in HL60 cells with MCT1 and MCT4 inhibition by restoring NAD+ levels and ATP depletion. Protects MC3T3-E1 cells from aluminum-induced oxidative stress, and inhibits thioredoxin-interacting protein. Reported to treat the pathophysiology of diet- and age-induced type 2 diabetes in mice. β-NMN ameliorates glucose intolerance by restoring NAD+ levels in type 2 diabetic mice models. β-NMN also enhances hepatic insulin sensitivity and restores gene expression related to inflammatory response, oxidative stress, and circadian rhythm, partly throμgh SIRT1. Reported to diminish several old age-associated pathologies. Restores SIRT1 activity and reverses age-related arterial dysfunction by decreasing oxidative stress in mouse models of aging. Reported to improve aging-induced cerebrovascular endothelial dysfunction and neurovascular coupling responses in old mice. Restores NAD+ and mitochondrial energetics and reduces mtROS in aged cerebromicrovascular endothelial cells. Promotes mesenchymal stromal cell.