SP600125 (RMML-00120961)
Cat. No.: RMML-00120961
Category: Inhibitors & Activators
INQUIRY
1 mg
5 mg
SP600125 is a potent and reversible inhibitor of JNK1-3. It is cell-permeable and dose-dependently inhibits c-JUN phosphorylation in cells, blocking the expression of COX-2 and TNF-α in monocytes and IL-10, TNF-α, and IFN- in T-cells. Direct lineage reprogramming of fibroblasts to mature neurons, in combination with CHIR99021, RepSox, Forskolin, Gö6983, Valproic Acid and Y-27632. Inhibits BMP9-induced osteogenic differentiation in cultured mouse mesenchymal stem cells. Promotes adipogenic, but represses osteogenic differentiation of human MSCs. Causes cell death and inhibits neurogenesis when added during early stages of neuronal culture.
Product Features
| Purity | ≥ 98% |
|---|---|
| Applications | Differentiation, Reprogramming |
| Cross Reactivity | Human, Mouse, Non-Human Primate, Other, Rat |
Compound Information
| Target Pathways | JNK |
|---|---|
| CAS Number | 129-56-6 |
| Molecular Formula | C₁₄H₈N₂O |
Storage & Shipping
| Handling | Refer to SDS for further information. |
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For research use only. Not for clinical use.
