Biotinylated Anti-Human EGF Polyclonal Antibody (RMAB-0251815)
Cat. No.: RMAB-0251815
Category: Primary Antibodies
INQUIRY
25 μg
50 μg
Product Features
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Immunogen | E.coli derived Recombinant Human EGF* *Catalog# 1-15 has been replaced with AF-1-15. |
Target Information
| Target Symbol | EGF |
|---|---|
| Target Name | Pro-epidermal growth factor |
| UniProt ID | P01133 |
| Cellular Localization | Membrane; Single-pass type I membrane protein. |
| Function | EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:1964941). |
| Involvement in Disease | Hypomagnesemia 4 (HOMG4): A disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to moderate psychomotor retardation, and brisk tendon reflexes. The disease is caused by variants affecting the gene represented in this entry. |
| Post-translational Modifications | O-glycosylated with core 1-like and core 2-like glycans. It is uncertain if Ser-954 or Thr-955 is O-glycosylated. The modification here shows glycan heterogeneity: HexHexNAc (major) and Hex2HexNAc2 (minor). |
For research use only. Not for clinical use.
