BIRB-796 (RMML-00120130)
Cat. No.: RMML-00120130
Category: Inhibitors & Activators
INQUIRY
1 mg
5 mg
BIRB-796 is a highly potent inhibitor of p38 MAPK. At 10 μM, BIRB-796 can also inhibit JNK2α2 in vitro, but at lower concentrations BIRB-796 inhibits p38 MAPK without affecting phosphorylation of JNK substrates. LRescues the self-renewal ability of muscle satellite cells from aged mice. Increases the regenerative capacity of functional aged skeletal muscle stem cells grown in hydrogel. Blocks GADD45G-induced differentiation of long-term repopulating hematopoietic stem cells. Enhances stem cell activity of cultured umbilical cord blood-derived hematopoietic cells cultured in serum-free medium supplemented with SCF, TPO, and FLT3L. Blocks the osteogenic differentiation effect of myocilin on human mesenchymal stem cells.
Product Features
| Purity | ≥ 98% |
|---|---|
| Applications | Expansion, Maintenance |
| Cross Reactivity | Human, Mouse, Non-Human Primate, Other, Rat |
Compound Information
| Target Pathways | p38 MAPK |
|---|---|
| CAS Number | 285983-48-4 |
| Molecular Formula | C₃₁H₃₇N₅O₃ |
Storage & Shipping
| Handling | Refer to SDS for further information. |
|---|
For research use only. Not for clinical use.
