RG 108, non-nucleoside DNA methyltransferase inhibitor (DNMT) (RMML-00120670)
Cat. No.: RMML-00120670
Category: Inhibitors & Activators
INQUIRY
50 mg
10 mg
Novel, non-nucleoside DNA methyltransferase inhibitor (DNMT)
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 99% |
| Key Features | Novel, non-nucleoside DNA methyltransferase inhibitor (DNMT); CAS Number: 48208-26-0; Purity: > 99%; Soluble in DMSO to 100 mM and in ethanol to 100 mM; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | non-nucleoside DNA methyltransferase |
|---|---|
| Biological Description | Novel, non-nucleoside DNA methyltransferase (DNMT) inhibitor, capable of interacting with the DNMT1 active site (IC50 = 115 nM). Inhibits DNA methylation in human cancer cell lines. Reactivates several epigenetically silenced tumour suppressor genes in vitro. Capable of enhancing the efficiency of induced pluripotent stem cell (iPS) generation. |
| CAS Number | 48208-26-0 |
| Chemical Name | N-Phthalyl-L-tryptophan |
| SMILES | O=C(O)[C@H](Cc2cnc1ccccc12)N4C(=O)c3ccccc3C4=O |
| Molecular Formula | C19H14N2O4 |
| Molecular Weight | 334.33 Da |
| PubChem Identifier | 702558 |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information. |
|---|---|
| Solubility | Soluble in DMSO to 100 mM and in ethanol to 100 mM |
| Storage & Shipping | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
For research use only. Not for clinical use.
