Compound E, gamma; -secretase inhibitor (RMML-00120184)
Cat. No.: RMML-00120184
Category: Inhibitors & Activators
INQUIRY
1 mg
250 μg
Cell-permeable, selective, non-competitive, potent γ-secretase inhibitor
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 99% |
| Key Features | Cell-permeable, selective, non-competitive, potent γ-secretase inhibitor; CAS Number: 209986-17-4; Purity: > 99%; Soluble in DMSO to 100 mM; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | gamma-Secretase |
|---|---|
| Biological Description | Cell-permeable, selective, non-competitive, potent γ-secretase inhibitor (IC50 = 0.3 nM). Active in vitro and in vivo. |
| CAS Number | 209986-17-4 |
| Chemical Name | N-[(1S)-2-[[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide |
| SMILES | C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2C(=N1)C3=CC=CC=C3)C)NC(=O)CC4=CC(=CC(=C4)F)F |
| Molecular Formula | C27H24F2N4O3 |
| Molecular Weight | 490.51 Da |
| PubChem Identifier | 11306390 |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. |
|---|---|
| Solubility | Soluble in DMSO to 100 mM |
| Storage & Shipping | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
For research use only. Not for clinical use.
