Dorsomorphin dihydrochloride, AMP-kinase inhibitor (RMML-00120834)
Cat. No.: RMML-00120834
Category: Inhibitors & Activators
INQUIRY
10 mg
50 mg
Potent, selective, reversible AMP-kinase inhibitor. BMP type I receptor inhibitor.
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 99% |
| Key Features | Potent, selective, reversible AMP-kinase inhibitor. BMP type I receptor inhibitor.; CAS Number: 1219168-18-9; Purity: > 99%; Soluble in water to 100 mM; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | AMP-kinase |
|---|---|
| Biological Description | Potent, selective, reversible AMP-kinase inhibitor (Ki = 109 nM). BMP type I receptor inhibitor. Induce autophagy in cancer cells independent of AMPK inhibition. Promotes cardiomyogenesis in embryonic stem cells. Reduces hepcidin, VCAM-1 and ICAM-1 expression in vivo. |
| CAS Number | 1219168-18-9 |
| Chemical Name | 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine dihydrochloride |
| SMILES | C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl |
| Molecular Formula | C24H25N5O.2HCl |
| Molecular Weight | 472.42 Da |
| PubChem Identifier | 49761481 |
Storage & Shipping
| Handling | Refer to SDS for further information. |
|---|---|
| Solubility | Soluble in water to 100 mM |
| Storage & Shipping | Store at -20°C (desiccating conditions). |
For research use only. Not for clinical use.
