CHIR99021, GSK3 inhibitor (RMML-00120785)
Cat. No.: RMML-00120785
Category: Inhibitors & Activators
INQUIRY
1 mg
5 mg
Potent, highly selective GSK3 inhibitor
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 98% |
| Key Features | Potent, highly selective GSK3 inhibitor; CAS Number: 252917-06-9; Purity: > 98%; Soluble in DMSO to 100 mM; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | GSK-3 |
|---|---|
| Biological Description | Potent, highly selective aminopyrimidine GSK3 inhibitor (IC50 values are 6.7 and 10 nM at GSK3β and GSK3α, respectively). Exhibits >500-fold selectivity for GSK3 against 20 closely related protein kinases and >800-fold selectivity for 23 additional enzymes and 22 receptors. Promotes self-renewal of mouse and human ESC due to β-catenin and c-Myc protein level stabilization. Commonly used in multiple stages of organoid generation. |
| CAS Number | 252917-06-9 |
| Chemical Name | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
| SMILES | N#CC(C=N1)=CC=C1NCCNC2=NC=C(C3=NC(C)=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2 |
| Molecular Formula | C22H18Cl2N8 |
| Molecular Weight | 465.34 Da |
| PubChem Identifier | 9956119 |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. |
|---|---|
| Solubility | Soluble in DMSO to 100 mM |
| Storage & Shipping | Shipped at 4°C. Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
For research use only. Not for clinical use.
