Dabrafenib (RMML-00120209)
Cat. No.: RMML-00120209
Category: Inhibitors & Activators
INQUIRY
1 mg
5 mg
Dabrafenib is a reversible, selective, and ATP-competitive inhibitor of B-RAF with higher potency towards V600E mutant B-RAF over wild-type B-RAF or C-RAF, with IC₅₀ values of 0. 8, 3. 2 and 5 nM, respectively. Decreases ERK phosphorylation and inhibits cell proliferation in cells expressing the B-RAF mutation V600E. Prevents tumor growth in mouse xenograft models of B-RAF(V600E) human melanoma and colon cancer. Alleviates acetaminophen-induced liver injury throμgh distinct nanomolar inhibition of receptor-interacting protein.
Product Features
| Purity | ≥ 98% |
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| Cross Reactivity | Human, Mouse, Non-Human Primate, Other, Rat |
Compound Information
| Target Pathways | MEK/ERK |
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| CAS Number | 1195765-45-7 |
| Molecular Formula | C₂₃H₂₀F₃N₅O₂S₂ |
Storage & Shipping
| Handling | Refer to SDS for further information. |
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For research use only. Not for clinical use.
