HS-1371 (RMML-00120770)
Cat. No.: RMML-00120770
Category: Inhibitors & Activators
INQUIRY
5 mg
potent RIP3 kinase inhibitor
Product Features
| Source | Synthetic |
|---|---|
| Purity | ≥ 98% |
| Key Features | Potent RIP3 kinase inhibitor; CAS Number: 2158197-70-5; Purity: ≥ 98%; >10 mg/mL DMSO; Form / State: Solid; Source: Synthetic |
Compound Information
| Biological Description | Potent RIP3 kinase inhibitor (IC50 = 20.8 nM). It binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro. . It inhibits TNF-induced necroptosis but does not inhibit TNF-induced apoptosis, indicating that HS-1371 has a specific inhibitory effect on RIP3-mediated necroptosis via the suppression of RIP3 kinase activity. |
|---|---|
| CAS Number | 2158197-70-5 |
| Chemical Name | 4-(4-methylphenoxy)-7-(1-piperidin-4-ylpyrazol-4-yl)quinoline |
| SMILES | CC1=CC=C(C=C1)OC2=C3C=CC(=CC3=NC=C2)C4=CN(N=C4)C5CCNCC5 |
| Molecular Formula | C24H24N4O |
| Molecular Weight | 384.47 Da |
| PubChem Identifier | 134817449 |
Storage & Shipping
| Handling | Refer to SDS for further information. |
|---|---|
| Solubility | >10 mg/mL DMSO |
| Storage & Shipping | Shipped at 4°C. Store at -20°C. |
For research use only. Not for clinical use.
