Fisetin

Promote senolytic activities by upregulating the expression of sirtuin 1. Fisetin inhibits DNA methyltransferase 1. Fisetin has been used for enhances survival of PC12 cells from tunicamycin. Downregulates phorbol-12-myristate 13-acetate plus calcium ionophore A23187. Inhibits the PI3K/Akt and mTOR pathway in prostate, lung, myeloma, and melanoma cancer cells. Known to possess antioxidant activity. Mechanistically, fisetin has been shown to attenuate H2O2-induced cell damage by scavenging ROS and activating GSH pathways in vitroInduces ERK activation which provides neuroprotective activities in Huntington’s disease models. Reduces senescence and age-related pathologies in yeast, simple eukaryotes, and mice.