Fludarabine (FAMP), DNA synthesis inhibitor (RMML-00120228)
Cat. No.: RMML-00120228
Category: Inhibitors & Activators
INQUIRY
50 mg
10 mg
DNA synthesis inhibitor. Prodrμg converted to active metabolite F-ara-A.
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 98% |
| Key Features | DNA synthesis inhibitor. Prodrμg converted to active metabolite F-ara-A.; CAS Number: 21679-14-1; Purity: > 98%; Soluble in DMSO to 100 mM; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | DNA synthesis |
|---|---|
| Biological Description | DNA synthesis inhibitor. Prodrμg converted to active metabolite F-ara-A which inhibits ribonucleotide reductase and competitively inhibits DNA polymerase. Also prevents DNA ligase I from joining DNA. Induces apoptosis. Active in vivo. |
| CAS Number | 21679-14-1 |
| Chemical Name | 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine |
| SMILES | Nc3nc(F)nc2c3ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O |
| Molecular Formula | C10H12FN5O4 |
| Molecular Weight | 285.23 Da |
| PubChem Identifier | 8975 |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information. |
|---|---|
| Solubility | Soluble in DMSO to 100 mM |
| Storage & Shipping | Store at 4°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
For research use only. Not for clinical use.
