U-0126

U-0126 is a selective, non-ATP competitive inhibitor of mitogen activated protein kinase kinase. It shows little or no inhibition at micromolar levels of other kinases such as ERK, protein kinase C. U-0126 also antagonizes AP-1 transcription and selectively inhibits promoters containing AP-1 response elements. & SELF-RENEWALIn combination with basic FGF, Activin A, and a PKC inhibitor, U-0126 promotes maintenance of human pluripotent stem cellsUsed alone with MEF-conditioned medium, U-0126 inhibits self-renewal of human pluripotent stem cells, leading to differentiation, without affecting proliferation or survival. Inhibits glutamate-induced oxidative stress in mouse hippocampal HT22 cells and rat primary cortical cultures. Neuroprotective in a gerbil ischemia model and in primary mouse neurons cultured under hypoxia. Inhibits T-cell proliferation against certain antigenic stimuli by reducing IL-2 mRNA levels. Activates peroxisome proliferator activated receptor.