Human CREBBP Antibody Pair - BSA and Azide free (RMAB-0252104)
Cat. No.: RMAB-0252104
Category: Antibody Pair
INQUIRY
10 x 96 tests
Human CREBBP Antibody Pair - BSA and Azide free is a matched pair of unconjugated recombinant rabbit monoclonal capture and detection antibodies used to (quantify Human CREBBP) in sandwich ELISAs and many other pair-based applications. _x000D_
Product Features
| Conjugate | Unconjugated capture and detector antibodies |
|---|---|
| Species Reactivity | Human |
| Range | 0.156 ng/mL - 20 ng/mL |
| Applications | Sandwich ELISA |
| Key Features | Unconjugated capture and detector antibodies; Adaptable to any antibody pair-based assay format; Antibody concentration ~ 1 mg/mL; BSA and azide free buffer - ready for conjugation; Reacts with: Human |
Target Information
| Target Symbol | CREBBP |
|---|---|
| Target Name | CREB-binding protein |
| UniProt ID | Q92793 |
| Cellular Localization | Cytoplasm. Nucleus. Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. |
| Function | Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 coactivator. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. |
| Involvement in Disease | Note=Chromosomalons involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8; 16)(p11; p13) with MYST3/MOZ; translocation t(11; 16)(q23; p13.3) with MLL/HRX; translocation t(10; 16)(q22; p13) with MYST4/MORF. MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1). RSTS1 is an autosomal dominant disorder characterized by craniofacialities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies. |
| Post-translational Modifications | Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response. Phosphorylated upon DNA damage, probably by ATM or ATR. Sumoylation negatively regulates transcriptional activity via the recruitment of DAAX. |
| Domain | The KIX domain mediates binding to HIV-1 Tat. |
| Sequence Similarities | Contains 1 bromo domain. Contains 1 KIX domain. Contains 2 TAZ-type zinc fingers. Contains 1 ZZ-type zinc finger. |
Storage & Shipping
| Storage & Shipping | Store at 4°C. Please refer to protocols. |
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For research use only. Not for clinical use.
