Human Fibronectin Matched Antibody Pair Kit (RMAB-0252020)
Cat. No.: RMAB-0252020
Category: Antibody Pair
INQUIRY
5 x 96 tests
Human Fibronectin Matched Antibody Pair Kits include a capture and a biotinylated detector antibody pair, along with a calibrated protein standard, suitable for sandwich ELISA. The Matched Antibody Pair Kit can be used to quantify native and recombinant human Fibronectin._x000D_
Product Features
| Species Reactivity | Human |
|---|---|
| Range | 62.5 pg/mL - 4000 pg/mL |
| Sensitivity | 17.7 pg/mL |
| Applications | ELISA |
| Key Features | Unlabeled capture antibody, biotin-labeled detection antibody and calibrated protein standard; For economical ELISA and ELISA-based assay development; Reacts with: Human; Range: 62.5 pg/mL - 4000 pg/mL |
Target Information
| Target Symbol | FN1 |
|---|---|
| Target Name | Fibronectin |
| UniProt ID | P02751 |
| Cellular Localization | Secreted, extracellular space, extracellular matrix. |
| Developmental Stage | Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age. |
| Function | Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. |
| Involvement in Disease | Glomerulopathy with fibronectin deposits 2 |
| Post-translational Modifications | Sulfated. It is not known whether both or only one of Thr-2064 and Thr-2065 are/is glycosylated. Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e. g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers). Phosphorylated by FAM20C in the extracellular medium. Proteolytic processing produces the C-terminal NC1 peptide, anastellin. |
| Sequence Similarities | Contains 12 fibronectin type-I domains. Contains 2 fibronectin type-II domains. Contains 16 fibronectin type-III domains. |
Storage & Shipping
| Storage & Shipping | Store at -20°C. Please refer to protocols. |
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For research use only. Not for clinical use.
